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S-Adenosylmethionine
SAMe
from Life Extension
Foundation
SUMMARY & QUICK ORDER
| PRODUCT #: |
10358 |
SAMe 200
mg |
| SIZE/COUNT: |
20 |
Depression |
| SUGGEST PRICE: |
$13.95
+ S&H |
|
|
SALE PRICE: |
$13.95
+ S&H |
 |
| PRODUCT #:
|
10453 |
SAMe 200 mg |
| SIZE/COUNT:
|
50 |
Depression |
| SUGGESTED PRICE: |
$
45.00 + S&H |
|
|
SALE PRICE: |
$ 32..95 + S&H |
|
|
ENHANCED BENEFITS WHEN
USED WITH: |
| Product #:
10335 |
DHEA |
Hormone |
| Product #:
10381 |
Ginkgo-Biloba |
Supplement |
SAMe
for depression, anxiety, sleep disorders. It is an important
natural substance produced by the body. A lack of SAMe can cause
liver damage, arthritis, cardiovascular problems,
depression, anxiety
and
sleep disorders. SAMe can be used safely and effectively as an
alternative to Prozac.
What is SAMe
?
 Read
what Dr. Richard Brown has to say about SAMe in his new book:
"Stop Depression Now"
SAMe, (which is also known as SAM or AdoMet)
is a synthetic form of a natural metabolite of the amino acid
methionine. SAMe is of great importance because it is a
cofactor in a number of critical biochemical reactions. SAMe is
the precursor for three fundamental biochemical pathways and it is
found in almost every tissue of the body. SAMe has been used in
clinical studies to treat depression,
anxiety,
schizophrenia, demyelination diseases,
liver disease, dementia, arthritis,
and other conditions. It was recently published in the Journal
of Neurochemistry that brain levels of SAMe in
Alzheimer's patients are severely decreased.
Why is
it so important?
S-Adenosylmethionine
SAMe, promises to be one of the most potent, multipurpose
antiaging, anti disease therapy identified by Medical science. It
is a natural metabolite of the amino acid methionine,
and SAMe appears to be a nontoxic, antiaging, health
enhancing blockbuster that could do wonders for every one of us. SAMe
is the most effective natural agent known for methylation in the
body - a process new research has shown to be a critical process
is preventative health. Not only does adequate methylation protect
the body from most serious diseases, a lack of it can trigger the
onset of diseases, including cancer. Aging symptoms are usually
caused by a deficiency in methylation, and taking SAMe is the
safest and fastest way to reverse this.
What Does SAMe Do?
On a cellular level, SAMe:
- Maintains mitochondrial function
- Prevents DNA mutations
- Restores cellular membrane
fluidity so that cell receptors become better able to bind
hormones and other factors
- Protects
the liver against alcohol, drugs and cytokines. It
protects against cholestasis (bile impairment or blockage).
It may protect against chronic active hepatitis. It protects
against liver damage caused by MAO inhibitors and
anticonvulsants. It reverses hyperbilirubinaemia.
- Protects against neuronal death
caused by lack of oxygen (anoxia). It regenerates nerves and
provokes remyelination of nerve fibers.
- Reduces the pain of arthritis,
and assist with join healing.
- May protect against heart
disease
- Has antidepressant
action equal to, and faster than FDA-approved drugs, and is
essential for the synthesis of melatonin.
- Assists
with sleep disorders,
particularly those which are induced by the side effects of
pharmaceutical drugs
LIVER
DISEASE
SAMe is the liver super-nutrient. Nothing comes close to
providing the spectrum of health benefits that SAMe provides for
the liver. Based on published clinical trials, elevating SAMe
levels can have a powerful effect on many conditions. As a
preventive agent, SAMe is so powerful that it can reverse the
effects of chemicals and alcohol as they occur. Studies show that
low SAMe levels create the conditions for liver cancer, and that
SAMe can prevent these conditions from occurring.
SAMe is the central player in liver biochemistry. It does two
crucial things: It methylates, and it transforms itself into the
liver's most vital substance, glutathione. Glutathione is crucial
for liver function. A good portion of liver SAMe is turned into
glutathione, which is the liver's natural antioxidant
ARTHRITIS
Research shows that SAMe
is an effective treatment for arthritis. According to the
Arthritis Foundation, 15.8 million Americans have osteoarthritis.
Another 2.1 million have rheumatoid arthritis, and 3.7 million
have fibromyalgia. After age 65, a person can almost count on
having some degree of osteoarthritis or osteoporosis
The standard treatment for arthritis hasn't changed in decades:
aspirin, steroids, NSAIDs (non-steroidal anti-inflammatory drugs),
gold treatments, immune-suppressing drugs, exercise and weight
loss, walking sticks and surgery. Although arthritis is usually
thought of as a cartilage disease, researchers at the University
of Bristol have discovered that bone is also involved. An enzyme
that degrades collagen is breaking down the lattice network inside
bone called "cancellous bone".
Clinical trials have proven that SAMe works for fibromyalgia
and osteoarthritis. New data indicates it may help rheumatoid
arthritis patients. It alleviates pain as well as NSAIDs, without
the side effects. Not only does it work as well as NSAIDs, it may
protect against the side effects these drugs
cause. SAMe
apparently counteracts cytokines, protects cartilage, inhibits
destructive free radicals, and may reverse the effects of
homocysteine on cartilage and/or inhibit enzymes. In clinical
trials, SAMe alleviated pain and improved mood.
SAMe is a substance which is naturally made in the body. No
serious side effects have ever been reported with SAMe, even in
high doses administered intravenously.
CHOLESTEROL
AND HEART DISEASE
A recent review in Archives of Internal Medicine dealt with
24,968 people in 34 studies who participated in trials of
cholesterol lowering regimens to prevent coronary artery disease.
The reviewers found that while lowering cholesterol by 10% or more
reduced the risk of dying of a heart attack in middle aged males
somewhat, no conclusions could be reached for women and elderly
people.
It appears that cholesterol may have less to do with heart
disease than the public has been led to believe. The recent data
on homocysteine and heart disease suggests that levels of SAMe and
its opposite, homocysteine, have more to do with heart disease
than cholesterol.
Beta blockers are a class of drugs used to treat heart
problems. Common brand names include Inderal, Tenormin, and
Lopressor (Toprol). People who take beta blockers to block beta
receptors in their heart, block receptors in their brains as well.
Blocking neal receptors interferes with the synthesis of melatonin.
The extent of the disruption caused by beta blockers to
circadian rhythms, and the important hormones that depend on these
rhythms was illustrated by an animal study showing that ingesting
a beta blocker before bedtime is like leaving the lights on all
night. Serotonin levels, which normally drop at night, remain
unnaturally high: SAMe doesn't decrease, and melatonin doesn't
increase. What occurs when beta blockers are taken before bedtime
looks a lot like sleep deprivation.
DEPRESSION
Depression occurs frequently with aging. It also occurs in
young people. SAMe (S-adenosylmethionine) is the best-documented
natural antidepressant in the world. There have been more than 100
peer-reviewed studies showing that SAMe works. It's faster-acting
with fewer side effects than other antidepressants, and SAMe is
safe. That's because it isn't a drug concocted in a chemistry lab.
It's a natural substance found in virtually every cell of the
body.
SAMe is indispensable for health and longevity. It's crucial
for the synthesis of neurotransmitters, DNA, RNA and
phosphatidylcholine, which keep cell membranes in a youthful
state. SAMe is the precursor for the free-radical-fighters
glutathione and cysteine. It contributes to the synthesis of
polyamines which regulate protein synthesis, and may play a key
role in energy production.
People who take beta blockers (at least in the evening) are
setting themselves up for insomnia, depression and other mental
disturbances due to the extraordinary interdependence of SAMe,
serotonin and melatonin. Beta blockers suppress serotonin as well
as melatonin. Thus, it is not surprising that the Physicians
Desk Reference lists mental depression, fatigue, short term
memory loss, insomnia and emotional lability as some of the
side effects of Inderal and other beta blockers.
ALZHEIMER'S
A recent study in the Journal of Neurochemistry reported that
Alzheimer's disease (AD) patients have severely decreased levels
of SAMe in their brains. This is an important discovery because it
was previously assumed from studies on blood cells that AD
patients had too much SAMe. Proper studies have never been done
with SAMe as a treatment for Alzheimer's disease because of this
erroneous assumption.
SLEEP
DISORDERS
SAMe is melatonin's daytime equivalent. The natural
synthesis of melatonin during the night is dependent on the
synthesis of SAMe during the day. SAMe is necessary for the
biochemical reaction that converts serotonin into melatonin. (Serotonin
is the neurotransmitter that drugs like Prozac elevate).
SAMe and melatonin are entwined in a circadian rhythm that
see-saws back and forth as the sun rises and sets. SAMe is
melatonin's other half: when melatonin levels shoot up at night,
SAMe stays low. But during the day, when melatonin falls, SAMe
levels climb. Without adequate SAMe during the day, neither
melatonin nor serotonin can be synthesized. And both are dependent
on light and dark.
Two benzodiazepine type drugs have been shown to suppress
melatonin and disrupt sleep patterns in humans and rodents. Valium
and Xanax both cause decreased production of melatonin at night.
In a study from the Niigata College of Pharmacy in Japan, Valium
also inhibited N-acetylserotonin and N-acetyltransferase, the
enzymes necessary for the synthesis of melatonin in the pineal
gland.
WARNING: Life
Extension Foundation, who produce this brand of SAMe has
recently undertaken an analysis of seven commercial brands of SAMe.
Two were found to have NO SAMe present; one had the wrong
form of SAMe and two others had less than 100% potency. So buyer
beware!
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